Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC034
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-22 13:09
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl PK Merz 1 ujutru tbl Requip modutab a 2mg 1 ujutru New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 9, 'TN': 8, 'TP': 33, 'FP': 22}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.26
timePerCircleCoV 0.0298317
timePerCircleSlope -0.00419403
meanError 1.50242
tremorFreq 9.375
tremorRelPower 22.0575
tremorGyroAmpMean 0.00907918
tremorGyroAmpSlope -0.0266938
tremorGyroAmpCoV 0.769482
tremorCoordAmpMean 0.0502371
tremorCoordAmpSlope -0.0154269
tremorCoordAmpCoV 0.323101
tremorAccAmpMean 0.0202908
tremorAccAmpSlope -0.0214193
tremorAccAmpCoV 0.724453
tremorPcRelVar 0.57089
tremorPcX 0.148412
tremorPcY 0.988926

Circle Segment 1

Duration 5.24 s, Accuracy Estimate 1.521 (lower is better)

Circle Segment 2

Duration 5.16 s, Accuracy Estimate 1.358 (lower is better)

Circle Segment 3

Duration 5.56 s, Accuracy Estimate 1.341 (lower is better)

Circle Segment 4

Duration 5.36 s, Accuracy Estimate 1.281 (lower is better)

Circle Segment 5

Duration 5.24 s, Accuracy Estimate 1.328 (lower is better)

Circle Segment 6

Duration 5.48 s, Accuracy Estimate 1.4 (lower is better)

Circle Segment 7

Duration 5.12 s, Accuracy Estimate 1.496 (lower is better)

Circle Segment 8

Duration 5.2 s, Accuracy Estimate 1.505 (lower is better)

Circle Segment 9

Duration 5.12 s, Accuracy Estimate 1.728 (lower is better)

Circle Segment 10

Duration 5.12 s, Accuracy Estimate 2.066 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 15.204
timePerSpiralCoV 0.0522282
timePerSpiralSlope -0.0086899
meanError 1.62975
tremorFreq 7.03125
tremorRelPower 18.2194
tremorGyroAmpMean 0.0109842
tremorGyroAmpSlope 0.00125057
tremorGyroAmpCoV 0.307922
tremorCoordAmpMean 0.0552586
tremorCoordAmpSlope 0.000382059
tremorCoordAmpCoV 0.505032
tremorAccAmpMean 0.022925
tremorAccAmpSlope 0.0016727
tremorAccAmpCoV 0.353834
tremorPcRelVar 0.507747
tremorPcX -0.743632
tremorPcY -0.668589

Spiral Segment 1

Duration 16.36 s, Accuracy Estimate 1.625 (lower is better)

Spiral Segment 2

Duration 15.24 s, Accuracy Estimate 1.472 (lower is better)

Spiral Segment 3

Duration 15.4 s, Accuracy Estimate 1.561 (lower is better)

Spiral Segment 4

Duration 15.68 s, Accuracy Estimate 1.642 (lower is better)

Spiral Segment 5

Duration 15.4 s, Accuracy Estimate 1.899 (lower is better)

Spiral Segment 6

Duration 13.96 s, Accuracy Estimate 1.716 (lower is better)

Spiral Segment 7

Duration 14.72 s, Accuracy Estimate 1.623 (lower is better)

Spiral Segment 8

Duration 15.64 s, Accuracy Estimate 1.595 (lower is better)

Spiral Segment 9

Duration 15.76 s, Accuracy Estimate 1.677 (lower is better)

Spiral Segment 10

Duration 13.88 s, Accuracy Estimate 1.487 (lower is better)

Elel

eDurationMean 0.421125
eDurationStd 0.101125
eDurationStdnorm 0.240131
eDurationMedian 0.4025
eDurationQuartdelta 0.1325
eDurationQuartdeltanorm 0.329193
eDurationKurt 6.97705
eDurationTrenddiff -0.105
eDurationTrendratio 0.766667
eWidthMean 4.5279
eWidthStd 1.49322
eWidthStdnorm 0.329781
eWidthMedian 4.446
eWidthQuartdelta 1.4625
eWidthQuartdeltanorm 0.328947
eWidthKurt 4.41173
eWidthTrenddiff -0.585
eWidthTrendratio 0.871795
eHeightMean 7.7922
eHeightStd 1.58015
eHeightStdnorm 0.202786
eHeightMedian 7.488
eHeightQuartdelta 2.691
eHeightQuartdeltanorm 0.359375
eHeightKurt 1.98503
eHeightTrenddiff -1.755
eHeightTrendratio 0.802632
eAspectMean 0.580713
eAspectStd 0.13551
eAspectStdnorm 0.233351
eAspectMedian 0.564091
eAspectQuartdelta 0.198211
eAspectQuartdeltanorm 0.351382
eAspectKurt 3.08978
eAspectTrenddiff 0.0933774
eAspectTrendratio 1.18073
eSlantMean 0.0523481
eSlantStd 0.198538
eSlantStdnorm 3.79265
eSlantMedian 0.0529412
eSlantQuartdelta 0.336384
eSlantQuartdeltanorm 6.35392
eSlantKurt 2.11061
eSlantTrenddiff 0.0301993
eRtopMean 0.779004
eRtopStd 0.0992651
eRtopStdnorm 0.127426
eRtopMedian 0.776389
eRtopQuartdelta 0.164915
eRtopQuartdeltanorm 0.212413
eRtopKurt 2.02168
eRtopTrenddiff -0.0233058
eRbotMean 0.728181
eRbotStd 0.305177
eRbotStdnorm 0.419094
eRbotMedian 0.704215
eRbotQuartdelta 0.516667
eRbotQuartdeltanorm 0.733677
eRbotKurt 1.98825
eRbotTrenddiff -0.0940917
eRrightMean 0.878581
eRrightStd 0.0859079
eRrightStdnorm 0.0977803
eRrightMedian 0.886019
eRrightQuartdelta 0.0921547
eRrightQuartdeltanorm 0.10401
eRrightKurt 3.58448
eRrightTrenddiff -0.0412834
eRleftMean 0.29249
eRleftStd 0.0715863
eRleftStdnorm 0.244748
eRleftMedian 0.282857
eRleftQuartdelta 0.105157
eRleftQuartdeltanorm 0.371766
eRleftKurt 2.23347
eRleftTrenddiff 0.0166772
lDurationMean 0.515769
lDurationStd 0.0975053
lDurationStdnorm 0.189048
lDurationMedian 0.525
lDurationQuartdelta 0.13125
lDurationQuartdeltanorm 0.25
lDurationKurt 2.49824
lDurationTrenddiff -0.12
lDurationTrendratio 0.789474
lWidthMean 6.534
lWidthStd 1.43107
lWidthStdnorm 0.21902
lWidthMedian 6.786
lWidthQuartdelta 1.78425
lWidthQuartdeltanorm 0.262931
lWidthKurt 2.93986
lWidthTrenddiff 0.702
lWidthTrendratio 1.11111
lHeightMean 16.062
lHeightStd 2.97712
lHeightStdnorm 0.185352
lHeightMedian 15.444
lHeightQuartdelta 3.89025
lHeightQuartdeltanorm 0.251894
lHeightKurt 2.81455
lHeightTrenddiff -3.861
lHeightTrendratio 0.784314
lAspectMean 0.418993
lAspectStd 0.110979
lAspectStdnorm 0.264871
lAspectMedian 0.420168
lAspectQuartdelta 0.150327
lAspectQuartdeltanorm 0.357778
lAspectKurt 2.68344
lAspectTrenddiff 0.123227
lAspectTrendratio 1.34465
lSlantMean 0.150427
lSlantStd 0.0923632
lSlantStdnorm 0.614005
lSlantMedian 0.151079
lSlantQuartdelta 0.127045
lSlantQuartdeltanorm 0.840917
lSlantKurt 3.49401
lSlantTrenddiff 0.0626784
lRtopMean 0.869056
lRtopStd 0.0661979
lRtopStdnorm 0.0761723
lRtopMedian 0.884615
lRtopQuartdelta 0.0444459
lRtopQuartdeltanorm 0.0502432
lRtopKurt 7.91759
lRtopTrenddiff 0.00226244
lRbotMean 0.529887
lRbotStd 0.167757
lRbotStdnorm 0.31659
lRbotMedian 0.521739
lRbotQuartdelta 0.264962
lRbotQuartdeltanorm 0.507845
lRbotKurt 2.13669
lRbotTrenddiff -0.0534022
lRrightMean 0.928533
lRrightStd 0.050257
lRrightStdnorm 0.0541252
lRrightMedian 0.928144
lRrightQuartdelta 0.0674246
lRrightQuartdeltanorm 0.0726445
lRrightKurt 2.82162
lRrightTrenddiff 0.0497199
lRleftMean 0.222985
lRleftStd 0.070848
lRleftStdnorm 0.317726
lRleftMedian 0.218182
lRleftQuartdelta 0.102049
lRleftQuartdeltanorm 0.467726
lRleftKurt 2.96308
lRleftTrenddiff -0.0040404

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.96875
sumTouchScores 31
meanMovementTime 0.592903
numTouches 32
undershootPercentage 3.125
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.966742
sumTouchScores 24.1685
meanMovementTime 0.77
numTouches 25
undershootPercentage 0
overshootPercentage 8

ZigZag

numZigzags 5
timePerZigzagMean 17.736
timePerZigzagCoV 0.0792506
timePerZigzagSlope -0.0469102
meanError 2.39064
tremorFreq 6.34766
tremorRelPower 17.3346
tremorGyroAmpMean 0.0136481
tremorGyroAmpSlope 0.0010492
tremorGyroAmpCoV 0.313764
tremorCoordAmpMean 0.137918
tremorCoordAmpSlope -0.00107244
tremorCoordAmpCoV 1.24654
tremorAccAmpMean 0.0500491
tremorAccAmpSlope 0.000325042
tremorAccAmpCoV 0.127886
tremorPcRelVar 0.867843
tremorPcX 0.060697
tremorPcY 0.998156

ZigZag Segment 1

Duration 19.96 s, Accuracy Estimate 2.122 (lower is better)

ZigZag Segment 2

Duration 18.24 s, Accuracy Estimate 2.369 (lower is better)

ZigZag Segment 3

Duration 17.2 s, Accuracy Estimate 2.375 (lower is better)

ZigZag Segment 4

Duration 16.72 s, Accuracy Estimate 2.498 (lower is better)

ZigZag Segment 5

Duration 16.56 s, Accuracy Estimate 2.589 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 9.376
timePerZigzagCoV 0.123485
timePerZigzagSlope -0.0699659
zigzagHeightMean 63.078
zigzagHeightCoV 0.00895989
zigzagHeightSlope -0.00359954
meanError 0.0349051
tremorFreq 8.69141
tremorRelPower 14.5525
tremorGyroAmpMean 0.0175508
tremorGyroAmpSlope 0.000337033
tremorGyroAmpCoV 0.340747
tremorCoordAmpMean 0.172716
tremorCoordAmpSlope 0.00716285
tremorCoordAmpCoV 1.22818
tremorAccAmpMean 0.0296401
tremorAccAmpSlope 0.00330933
tremorAccAmpCoV 0.247673
tremorPcRelVar 0.932677
tremorPcX -0.295702
tremorPcY 0.95528

ZigZag Offset Segment 1

Duration 11.32 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 2

Duration 9.4 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 8.96 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 4

Duration 8.92 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 8.28 s, Accuracy Estimate 0.042 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.18827623493497714}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8839710060439812}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.47878504810881045}